Is this the reason that the Pope resigned?

The Pope does not believe every Pope is the choice of the Holy Spirit.  He may not believe he was the choice of the Holy Spirit

"I would not say so, in the sense that the Holy Spirit picks out the Pope. … I would say that the Spirit does not exactly take control of the affair, but rather like a good educator, as it were, leaves us much space, much freedom, without entirely abandoning us. Thus the Spirit’s role should be understood in a much more elastic sense, not that he dictates the candidate for whom one must vote. Probably the only assurance he offers is that the thing cannot be totally ruined.

Then the clincher:
There are too many contrary instances of popes the Holy Spirit obviously would not have picked!"

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